The authors discuss the results of the development of the new master version of the State Rubricator of Sci-tech information (SRSTI, GRNTI) in part of the Natural and Sciences and STEM. The following information objects are analyzed: SRSTI 2022 classification tables as amended and supplemented in 2023; RF Basic Research Program for 2021–2030; verified version of the Nomenclature of Scientific Specialties of Higher Attestation Commission (VAK); List of Priority High-end Technologies approved by the RF Presidential Decree No. 529 of June 18, 2024; RNPLS&T’s inflow of sci-tech literature classified by SRSTI classes. Based on the analysis, the necessary changes are identified to be incorporated into the thematic classes of the section Natural Sciences and STEM of the valid SRSTI version to provide relevance of SRSTI new version to the current status and trends of the natural sciences. The authors cite the following statistical data: 252 new subject headings, 21 headings excluded, and updated descriptions of 151 headings.