The authors explore the structural changes in scientific collaborations in Siberian regions applying the method of scientometrical analysis of publications. After many years of growth, in 2022–2023 the scientific cooperation of Russian institutions with those in Europe and North America drastically reduced. The most significant changes took place in Novosibirsk and Tomsk regions that earlier had been leading in international collaborations. In the other Siberian regions the decline is less significant. Every discipline experiences the recession, moreover in many cases the scientific contacts with China and Kazakhstan have decreased, too. Notably, Krasnoyarsk region has upgraded its interaction with India, Uzbekistan and Saudi Arabia, while Irkutsk and Novosibirsk regions have maintained their cooperation with Mongolia. The Siberian regional cooperation has been stagnating under the dominance of the capital city, Novosibirsk region leads less often, and Tomsk region is ranked third. Interaction with the Ural region, i. e. Sverdlovskaya, Tyumen and Chelyabinsk regions, are still intensive and covers the wide range of disciplines, while the ties with the Russian Far East are rather weak.