TThe article raises the issues of scientific support for the development of librarianship in the conditions of digitalization. It presents the analysis of the scientific agenda of library and information sciences, laid down in the “Strategy for the development of librarianship in the Russian Federation until 2030”. The possibilities of solving problems relevant to the industry within the framework of the new nomenclature and passport of the scientific specialty “Library Science, Bibliography and Book Studies” are critically evaluated. It is proposed to consider the nomenclature of scientific specialties as a system integrity, within which the search for areas of interdisciplinary interaction and migration to other scientific specialties is carried out at the level of the subject of research. The scientific specialties that have theoretical and organizational potential for research and development of issues of digital development of librarianship have been identified. The ways of harmonization of library and information sciences with the new positions of the specialty 5.10.4 and a new field of science – cultural studies have been defined, the task of determining the direction of scientific research has been set. The possibilities of studying library and information issues in line with the research of the actual problems of digitalization of culture as one of the branches in which library construction is actively conducted have been analyzed, their connection with the priorities of scientific and technological development has been determined. The definition of digitalization of culture is given as a set of new IT solutions, new design of the cultural information space, new relationships in the professional and social environment, new economic models, new cultural codes. Among the promising areas of research that are important for the development of librarianship in the modern conditions there have been defined: digitalization of cultural heritage preservation (scientific tasks that make up the “technical” and “humanitarian” streams are highlighted); digital resources of culture and art and electronic libraries (a single digital space of culture as a theoretical concept and strategic guideline); digitalization of creative industries and digitalization of everyday cultural practices; digital reading infrastructure; human problems in digital culture; digital formats of “documenting culture”; digitalization of culture in the context of intellectual property; digital humanities.