The studies of interaction between scientific libraries are seen as incomplete and fragmentary. Understanding this phenomenon of library practice would enable to reveal the objective reasons why the ties have weakened, and to predict the conditions for increasing the potential of scientific libraries (SL) in the region. The author discusses the scientific libraries typology, the forms of their interaction, and attempts to introduce the model of their interaction. She describes the scientific libraries practice of cooperation traditional for Krasnoyarsk, with the focus on the Central Regional Library of Krasnoyarsk region, the Central Scientific Library of the Krasnoyarsk Science Center of the Russian Academy of Sciences Siberian Branch (SB RAS) and academic libraries, all as the part of the regional scientific and educational space. The forms of interaction between the Krasnoyarsk scientific libraries made the subject matter of the retrospective study. The historical research method and the analysis of publications enabled to identify active, unstable, and weakening aspects of SL interaction. The author reviewed the publications by Russian library researchers and Krasnoyarsk academic librarians. The study findings reflect the general picture of interaction between Krasnoyarsk scientific libraries and would enable to foster the efforts to strengthen professional communication.