The antibacterial activity of 25 samples of essential oils and seven aqueous samples and ethanolic plant extracts was evaluated against the complex of potato blackleg pathogens Dickeya chrysanthemi, Pectobacterium odoriferum, Dickeya didantii and Pectobacterium carotovorum subsp. carotovorum. To identify the described species, studies of pathogens were carried out in vitro with a skin diffusion test on agar, requiring minimal inhibitory (MIC) and minimal bactericidal concentrations (MBC) of essential oils and plant extracts. Based on the results of screening for studies in the field of health, in vivo conditions, the essential oils of the common oregano, Chinese cinnamon, clove, as well as ethanol extracts of thick-leaved badan and common oak bark were selected. In the course of further testing, the ability of essential oils and extracts to prevent potato tuber maceration when used for prophylactic and therapeutic purposes was evaluated. With therapeutic use of the above essential oils at a concentration of 40 mg/ml or more and plant extracts at a concentration of 150 mg/ml or more, the biological effectiveness was 12.4–48.7%, and with prophylactic use – 35.3–100%. GC–MS and GC-FID analyzes showed that the main component of oregano essential oil was carvacrol (62.32%), Chinese cinnamon – cinnamaldehyde (84.25%), clove – eugenol (76.98%). Acetic (27.85%) and caproic (28.52%) acids predominated in the compositions of the extracts of thick-leaved badan and common oak, respectively.