The third scientific and practical conference “The letters and digits: The libraries on the way to digitalization” “BilioPiter–2022” is reviewed. The conference w as h eld i n S t. P etersburg o n A pril 6–8, 2022. Every year, the conference gathers together library professionals, educationalists and researchers to contribute to the development of library and information sphere. The conference key topic is discussed: joint efforts of the libraries and educational, informational and research organizations in developing new approaches, methods and technologies for the library and information sphere in the modern digital environment. The focus is made on specialized research and practical seminar “Automation of libraries in the digital information educational environment” and IRBIS School one-day session (St. Petersburg State Institute of Culture); lecture-seminar series “The libraries in the modern information and digital environment “Concepts, technologies, laws and regulations”; discussion round table “The libraries’ interacting with the society, business and authorities”; presentation of the memorial threevolume book “My friend Katya Genieva” (V. V. Mayakovsky Central City Public Library); special seminar “Information support of science and Education: Theory and practice” (National Library of Russia); and special seminar “The projects of the National Library of Russia in digitalization of the national cultural heritage” (Russian Academy of Science Library). The key topics and keynote papers are also discussed.