The study aims to conduct a comprehensive historical analysis of the evolution of the Timiryazev Academy (Russian State Agrarian University – Moscow Timiryazev Agricultural Academy) from its foundation in 1865 to the present day, to identify patterns of continuity in scientific and educational traditions, as well as to summarize the experience of adapting agricultural education to the political, social, and economic challenges of different eras, including repressions, wars, reforms, and crises. The methodological framework of the study is based on the principles of historicism and systemic analysis, implemented through problem-chronological, historical-genetic, comparative-historical, and institutional approaches. A critical analysis of archival sources from the collections of the State Archive of the Russian Federation (GARF), the Russian State Archive of the Economy (RGAE), the Central Historical Archive of Moscow (TsIAM), the Central Archive of the Ministry of Defence (TsAMO), and the History Museum of the Timiryazev Academy has enabled the reconstruction of a reliable historical narrative, free from the contextual layers of previous historiography. The study presents, for the first time in historical literature, a holistic reconstruction of the 160-year journey of the university – from the liberal Petrovskaya Agricultural and Forestry Academy, through the strict regulation of the Moscow Agricultural Institute, Soviet transformations, wartime heroism, and survival in the 1990s, to its current status as a national treasure and innovation leader. It establishes that the key factor in the academy’s sustainability has been the continuity of scientific schools, which has preserved the foundations of agronomic thought despite repressions and ideological pressure. Additionally, the study has identified the university’s strategic triune function at all stages: ensuring food security, training personnel for national defence, and modernizing the agro-industrial sector. The significance of the study lies in filling a gap in historiography, where no comprehensive works have previously covered the pre-revolutionary, Soviet, and post-Soviet periods as a unified whole. The materials of the article can be used in preparing works on the history of agricultural education, in museum and educational activities, and in developing strategies for the advancement of agricultural universities, taking into account the historical experience of crisis adaptation. This is particularly relevant in the context of contemporary challenges related to ensuring Russia’s scientific and technological independence and food sovereignty.