The grain industry underpins the development of the national agro-food market, influencing a wide range of social, economic, and environmental factors that determine the sustainable development of the agro-industrial sector. This research aims to develop a conceptual framework for the grain industry development in the Southern Federal District of the Russian Federation, considering global agro-food market trends such as climate change, risk management, production greening, digitalization, globalization, state support, and evolving consumer values. Using data from the Southern Federal District, the study highlights the characteristics of grain farming in a market economy undergoing digital transformation and defines the goals and objectives for the industry development. It also examines global trends impacting the Russian grain industry. The research identifies key conditions for the efficient functioning of the grain industry and proposes a system of principles to underpin the concept of its development in the Southern Federal District. The role of digital technologies in transitioning to an adaptive-intensive grain production system is explored, and the largest grain exporters within the Southern Federal District are identified, along with their export volumes and destinations. Furthermore, the study addresses technical, technological, macroeconomic, and social risks that are expected to impact the district’s grain industry in the short and medium term. Finally, a forecast for the development of the grain industry in the Southern Federal District until 2030 is presented, based on key indicators that ensure an effective system for grain production, processing, and sales, and enhance export potential.