This article examines the scientific and pedagogical activities of Igor I. Grandberg, a prominent Soviet and Russian scientist in the field of organic chemistry, Honored Scientist of the Russian Federation, Doctor of Chemical Sciences, and Professor. A brief biography of the scientist is presented, showcasing his contribution to both national and global science. I. I. Grandberg’s scientific interests were focused on the development of novel synthetic methods and the study of the chemical and biological properties of heterocyclic compounds. In this area of chemistry, he discovered a significant new reaction, which the international scientific community subsequently named the “Grandberg Reaction.” The article also discusses his achievements in studying the mechanisms of chemical reactions and solving applied problems for various sectors of the national economy. Furthermore, the significant contribution of I. I. Grandberg to the training of specialists for the country’s agro-industrial sector is discussed, particularly through his repeatedly reissued textbook “Organic Chemistry” for bachelor’s and specialist degree students in agricultural, biological, and medical areas.