Realizing the genetic potential of monogastric animals depends on a well-functioning gastrointestinal tract, which not only digests and absorbs nutrients but also protects against harmful microflora. This intestinal function is energetically expensive, requiring up to 40% of daily protein and energy intake to support rapid enterocyte turnover – these cells are replaced approximately every three days. This article reviews current perspectives on using probiotics, prebiotics, and butyric acid-based complexes in modern industrial pig and poultry farming. Studies examining the effects of probiotics with varying compositions on the gastrointestinal microflora of monogastric animals are discussed. Furthermore, the article highlights how these feed additives can enhance animal resistance to intestinal diseases by inhibiting pathogen colonization, boosting immunity, and improving nutrient availability in poultry and pigs.