The purpose of the article is, basing on the results of studying the experience of interaction between scientific libraries of Siberia and the Far East in the 20th – first decades of the 21st century, to determine trends in the development of libraries, goals and objectives of the State Public Scientific Technological Library of the Siberian Branch (SPSTL SB RAS) when working out the project for the development of multidisciplinary scientific libraries, libraries of scientific institutions and universities in the region in 2025–2030 in accordance with the priority directions of the State scientific, technological, socio-cultural policy of the Russian Federation. A brief history and dynamics of the formation of the network of libraries of scientific institutions and universities, branch and multidisciplinary libraries in Siberia and the Far East are presented – an important part of the information support of specialists in scientific, educational and industrial complexes. The role of the State Public Scientific Technological Library of the Siberian Branch (SB) of the Academy of Sciences (AS) of the USSR – SB of the Russian Academy of Sciences (RAN) – the leading multidisciplinary scientific and technological library, an information and methodological center for academic libraries; which was in the 1960s–1990s the coordination center of libraries of scientific institutions, largest universities, industry and central scientific libraries of provinces, territories and republics of the region is examined. In connection with the adoption of a number of legislative acts in 2013–2024 and the transformation of scientific libraries activities, the need to work out and implement the project for the development of multidisciplinary scientific libraries, libraries of scientific institutions and universities in Siberia and the Far East is substantiated.