The paper justifies consideration of migration processes as a socio-cultural determinant, which shapes the formation, dynamics and transformation of interethnic communities. The general conceptual provisions are supported by conclusions obtained by generalization of the historical experience of the development of ethno-social processes and interethnic communities in Siberia. It is shown that their qualitative characteristics are due to the main migration waves, beginning with the annexation of Siberia to Russia in the 16th century. Since this period, the Russian population that moved here had a decisive influence on the development of indigenous peoples. The modern socio-economic and ethno-cultural appearance of Siberia is largely a product of migration processes. Geopolitical, internal political, economic factors of migration processes and the basic tendencies of change under their influence of interethnic communities of Siberia are singled out.