The article summarizes the outcomes of the International Scientific Conference “Agrobiotechnology-2021”, which took place November 24-25, 2021, in Russian State Agrarian University - Moscow Timiryazev Agricultural Academy. Scientists presented results of their research in the following sections: “Plant growing, grassland science, farming”, “Plant protection”, “Safety and quality of agricultural raw materials and food”, “Biotechnology, breeding and seed production of agricultural plants”, “Horticulture and medicinal plants”. The main emphasis was on the research on the development of resource-saving agro-biotechnologies. It is one of the priorities in implementing programs of the Russian Federation Government in the field of food safety till 2030 and tasks on the self-sufficiency of the country in primary domestic agricultural produce, raw material, and foodstuffs. The conference participants discussed the concept and prospects of organic farming in Russia, issues of crop production sustainability and its functioning, ways to overcome factors negatively affecting yield formation and crop quality. They tried to find ways to improve natural and old grasslands. The researchers analyzed climate change and related cultivation technology and agronomic practices, soil cultivation methods, weed control, and herbicide use. The participants put forward theses on the importance of crop rotation combined with advanced farming practices. The conference addressed yield loss issues in crop production due to unfavorable conditions of the vegetation period: frost, drought, overwatering, and other stressful situations for plants. The participants suggested resource-saving, soil-protective, energy-saving techniques, and search for new environmentally safe plant seed growth stimulants. They discussed critical factors of plant nutrition and phytosanitary status of soils, soil formation. The conference addresses the challenges of global climate change associated with steadily increasing average annual temperatures, new breeding methods, and seed production as the basis of agricultural production.