In view of the important role of microelements in the physiological and biochemical processes in plants, the study of new types of microfertilizers is of undoubted interest, both in theoretical and practical terms. The possibility of using microelement complexes together with chemical and biological plant protection products makes it possible to combine the terms of their use and increase the biological effectiveness of preparations. At the same time, the effectiveness of microfertilizers largely depends on the degree of soil cultivation, which served as the basis for this research. The paper presents the results of the use of microfertilizers in combination with mineral fertilizers for winter wheat of the Moskovskaya 56 variety and spring barley of the NUR variety, obtained in two long-term field experiments on soddy-podzolic heavy loamy soil of the Moscow Region. The use of the microelement complex “Microel” against the background of an organo-mineral fertilizer system on well-cultivated soddy-podzolic soil increased the yield of winter wheat by 8%, spring barley – by 9%, and the use of microfertilizer “Aquamix-t” – by 21% and 13% respectively. The introduction of zinc microfertilizers on poorly cultivated soil against the background of liming at pHKCl 5.4 contributed to an increase in the yield of winter wheat by 10%, spring barley – by 12% with a yield against the background of NPK of 5.90 t/ha and 4.42 t/ha, respectively. With the complex use of macro- and microfertilizers, grain quality indicators significantly increase: the content of protein, crude gluten, and the weight of 1000 grains.