The economic, social and political transformations that took place in the country in the 21st century, including the reforms at the Russian Academy of Sciences (RAS) in 2013, significantly affected the activities of its information and library system, which is the subject of discussion at various forums of professionals. Experts are discussing the idea of the need to create a methodological association of library and information institutions, which are now under the jurisdiction of the Ministry of Science and Higher Education of the Russian Federation, on the formation of regional methodological associations of scientific libraries for the sustainable development of the system of information and library support for science in the country. A brief description of the regional information and library system is presented – the system of scientific libraries of institutions of the Siberian Branch of the Russian Academy of Sciences, the information and library council of scientific institutions - an advisory body designed to help library services to scientists, which operated in 1958–2012, and the experience of the State Public Scientific Library of the Siberian Branch of the Russian Academy of Sciences in information and methodological support for the activities of the libraries of institutes. The directions of reconstruction of the system of interaction between libraries of scientific institutions, the activities of the emerging Siberian Association of Academic Libraries are outlined. The work of the SPSTL SB RAS – the largest scientific library in Siberia - to promote library and information resources for users of libraries of research institutions is described in detail and information is provided on the scientific and methodological support for the activities of scientific libraries carried out by the SPSTL SB RAS, which contributes to the successful implementation of the tasks of developing the scientific and information sphere.