Currently, there is a heightened demand for off-season raspberry fruit. Consequently, the aim of this work was to investigate the effect of the biostimulant Isabion on the growth characteristics and productivity of red raspberry plants of the remontant type of fruiting under the conditions of the Central Black Earth Region. This study presents the results of three-year observations on the effect of the plant growth biostimulant Isabion on increasing the productivity of introduced cultivars of remontant raspberries Polka, Polyana, Shugana, Utrennyaya Rosa, with the domestic cultivar Zhar-Ptitsa serving as the control. Three foliar applications of Isabion (8 ml/l) promoted the activation of vegetative growth and productivity in the experimental plants, which is likely associated with enhanced metabolic processes. During the observation period, in the experimental treatments, the shoot height of the studied cultivars increased by an average of 10–15 %, the number of laterals per shoot by 1.9–3.1, berry weight by 14.5–19.2%, and raspberry plantation yield by 15–20 % compared to the control. The largest-fruited cultivars were Shugana and Utrennyaya Rosa, with berry weights of 6.3 g and 5.6 g, respectively. The small-fruited cultivar Polyana exhibited high responsiveness to the treatment, showing an increase in average berry weight by 19.2 %. The research demonstrated that the inclusion of foliar feeding with a physiologically active preparation (Isabion), containing a complex of amino acids and peptides, into the technological cultivation protocol for remontant raspberries resulted in an average yield increase of 15–20 % across cultivars. The highest yields were recorded for cultivars Polka (24.4 t/ha) and Shugana (33.7 t/ha).