The article presents the results of research on the effectiveness of ammophos, sulfoammophos and urea modified with nitrification (DMPP) and urease (NBPT) inhibitors when applied to spring wheat. Field experiments were carried out in 2022–23 on cultivated light loamy soddy-podzolic soil on the territory of the Field Experimental Station of the Russian State Agrarian University – Moscow Timiryazev Agricultural Academy. It has been shown, that the application of inhibitors with ammophoska and urea increases grain yield by 12–14% and increases protein yield by 10–15%. The application of nitrification and urease inhibitors ensured a higher content of mineral forms of nitrogen in the soil during the growing season and more efficient use of fertilizer nitrogen by plants. The nitrogen utilization coefficients of sulfoammophos, ammophoska and urea increased by 2%, 10% and 18%, respectively, under the influence of the nitrification inhibitor. The application of urease inhibitor together with urea increased the nitrogen utilization coefficient by 12%. The payback of fertilizers in grain yield increased by 1.9–7.1 kg/kg under the effect of inhibitors.