The content of secondary metabolites in plants varies greatly depending on weather and climate conditions, therefore, an urgent problem in medicinal plant breeding is the assessment of taxa for the stability content of target compounds in different weather years and the identification of the most predictable species by this parameter. The work assesses 14 economically significant species from the Lamiaceae family. Many species of the Lamiaceae family are considered as popular medicinal, essential oil and spice-aromatic plants due to the content of biologically active compounds with multifunctional action. The aim of the work is a comparative assessment of Lamiaceae family representatives in terms of the stability of the raw material composition depending on the weather and climatic conditions of the year. To achieve this, the content of phenolic compounds in the studied species was determined and their comparative characteristics were provided. The content of phenolic compounds reflects the total amount of different groups of secondary metabolites. They include simple phenols, flavonoids, tannins, and phenolic carboxylic acids. As a result of 4-year observations, the following species should be noted as stable in terms of phenolic compound content under various weather and climate conditions: Satureja hortensis (coefficient of variation 3.48%), Origanum vulgare (coefficient of variation 4.11%), Hyssopus officinalis (coefficient of variation 5.59%), Thymus vulgaris (coefficient of variation 8.21%), Monarda fistulosa (coefficient of variation 9.5%) and Dracocephalum moldavica (coefficient of variation 9.71%). Consequently, these plants will have the most predictable indicators of phenolic compound content and raw material quality for further use and processing.