The study analyzed the genetic diversity of polymorphism in the calpain ( CAPN1 ) and leptin ( LEP ) genes in ewes and rams of the Kalmyk fat-tailed breed and the influence of different genotypes on their live weight and average daily gain. It was found that the proportion of the C allele in the CAPN1 locus was higher in rams, while the T and C alleles were equally frequent in ewes. The T allele was more common in ewes and rams than in the parent stock. In the LEP locus, animals with the AG genotype were most common. No deviations from the Hardy-Weinberg equilibrium were found for either locus. Ewes and rams of different genotypes for the CAPN1 gene did not differ in live weight at birth, but by the age of weaning, both rams and ewes with the CC genotype outperformed the young animals of other genotypes. No reliable differences were found between the live weight and average daily gain in ewes and rams of different genotypes for the LEP gene, except that the rams of the AA genotype were characterized by a higher live weight at birth than their peers. It was found that stud rams with the AA genotype were significantly inferior in live weight to rams with other genotypes, while ewes with the AA genotype outperformed ewes of other groups in this trait.