The research work is devoted to studying the main clinical, laboratory and echographic manifestations of pyometra in dogs and assessing their significance in the diagnostics of open and closed forms of the disease. It was found that the open clinical form of pyometra is much more common ( 77.78% vs. 22.22% ) than the closed one. Pathological discharge from the vulva serves as a cardinal symptom of the open form of pyometra and allows to clearly differentiate it from the closed form. Common systemic clinical and laboratory manifestations of the open and closed forms of pyometra are hyporexia / anorexia, lethargy, polyuria / polydipsia, hyper / hypothermia, neutrophilic leukocytosis and monocytosis. In the closed form of pyometra, leukopenia, neutropenia and lymphocytopenia are also more common. Complex ultrasound ( in Band D-modes ) is widely used and highly informative method of diagnosing pyometra in bitches. Ultrasound examinations in B-mode allow to visually determine the presence of inflammatory changes in the uterus ( for example, it is possible to determine the dilatation of the lumen of the uterine horns with hypoechoic contents ( pus ) , an increase in the thickness of the uterine walls and / or the presence of formations of various sizes in the endometrium such as cysts ) . Research in Dallows the parameters of uterine blood flow to assess the nature and activity of the pathologic process. Disorders in the hemodynamics of the uterus in the closed form of the pyometra are, as a rule, more pronounced than in the open clinical form of the disease.