As a result of global climate change towards warming, the whole world is faced with the problem of producing grape raw material with high sugar content and poor phenolic ripening. To eliminate this imbalance in the degree of ripening of grape raw material caused by natural anomalies, we tested fertilizers of various chemical and biochemical compositions and natural foliar biostimulants. The aim of the research was to study the effect of preparations of different spectrum of foliar action on the harmonization of sugar accumulation and phenolic ripening in grapes, and the quality of wine of the variety Krasnostop AZOS. In the current situation of unstable weather conditions in the existing terroir conditions with the established varietal composition of the vineyards, it is very relevant to identify preparations that can optimize the processes of grape ripening to preserve the quality parameters of wine. Preparations with various spectrums of foliar action will be studied: CAGS complex amino acid-humic fertilizer with vitamins and microelements; Chlorella extract ( an amino acid complex from algae, the extract of which is a highly effective biostimulant ) ; Agrumax ( mineral complex ) ; Biodux – a derivative of the fungus Mortierella alpina, a biologically active preparation of arachidonic acid; technical red grape variety bred by AZOSViV – branch of the FSBSI NCFCHVW “Krasnostop AZOS”; must and wine from the variety Krasnostop AZOS. Methods of technochemical and microbiological control in winemaking were applied in the work; wine parameters were determined according to GOST methods and original certified methods of the Instrument-Analytical winemaking center of the NCFCHVW; polyphenolic and anthocyanin substances in wine were studied using the technique of V.G. Gerzhikova, Research Institute “Magarach”. Agricultural technology is generally accepted, adapted to the local terroir. Work on studying radically different active substance preparations for the quality of grapes and wine showed that the highest statistically proven yield of the variety Krasnostop AZOS, statistically proven at the 95% significance level, was recorded as a result of application of the preparations CAGS and Biodux; the analysis of wines from the variety Krasnostop AZOS and their organoleptic evaluation allows us to conclude that with the increase of the concentration of the extract, phenolic substances, and the total content of biologically active substances in it, the hygienic value and the general quality of the wine itself increase; the highest tasting scores were given to wine samples from the variants of treating grapes with foliar preparations from the group of biologically active substances: Chlorella algae extract and Biodux.