In 2016, the Dorper rams were brought to the Republic of Kalmykia. In the Russian Federation, this breed is new and there is little data on its use when crossed with other breeds. The research purpose was to study the effectiveness of crossing the ewes of the Kalmyk fat-tailed breed with rams of the Dorper breed, as well as the economically valuable qualities and biological features of the resulting hybrids in the conditions of the arid zone of Kalmykia. It was established that breeding efficiency (impregnation rate) in ewes of the experimental group was higher by 2.5%, and fertility (birth rate) was higher by 7.5% as compared to the control group. Mixed bred youngsters featured increased growth energy during all growing periods and reliably exceeded their peers of the control group at all ages in terms of live weight, as well as absolute, average daily, and relative increase in live weight. Animals showed a high blood content of hemoglobin, leukocytes, erythrocytes, total protein, albumin, alkaline phosphatase, and increased activity of transamination enzymes (ATT) and (ALT), which indicates the activation of redox processes in their bodies. Rams of the experimental group outperformed their peers from the control group in pre-slaughter weight by 6.03 kg, chilled carcass mass by 4.79 kg, slaughter yield by 5.19%, pulp mass by 3.99 kg, bones, cartilage and tendons by 0.8 kg The largest mass of Class I cuts was found in the carcasses of hybrid sheep and it amounted to 17.16 kg, which is 4.42 kg higher than that of purebred peers. Muscle tissue of hybrids contained more dry matter, protein and fat. It was characterized by a greater water-holding capacity of 2.8 7%. The content of amino acids in the meat of hybrid sheep was higher than that of control animals. Chemical and physico-chemical properties of tail fat proved to be of a good quality.