The article presents a brief retrospective of the conceptions of philosophical postmodernism in their connection with posthumanism. Posthumanism is a philosophical movement that has been actively developed in the last decade, with its roots in the 60s and 70s of continental philosophy. The discourse of posthumanism implies work and development of conceptions and notions used by M. Foucault, J. Derrida, J. Deleuze and F. Guattari, R. Barthes and others. Connecting with such philosophical trends as disability studies, animal studies, postcolonial philosophy, actor-network theory, intersectional feminism, posthumanism expands, complements and reincarnates many provisions of postmodern philosophy. This article outlines the main concepts used in posthumanist discourse.