The irrigated conditions of the Lower Volga region are characterised by long, very hot and often dry summers, which are favourable both for vegetables and for the development of weeds. Weed growth is a major cause of crop obscuration, pest and disease infestation, and yield loss. The main objective of the study was to develop an economically viable and effective system for protecting bulb onions from annual weeds under drip irrigation in the arid climate of the Astrakhan region. The results of testing the herbicides Goal 2E, KE and Lazurite, SP based on the active substance metribuzine in irrigated land use conditions of Precaspian Agrarian Federal Scientific Center of Russian Academy of Sciences for the period from 2020 to 2022 are presented. Among the weeds present were: a bluish, thrown-back cheek, milkweed, garden swan, wheatgrass, field finch, common solyanka (kurai), gorchak. Herbicide treatment significantly reduced the number of weeds in the onion crop, especially in the varieties where Lazurite, SP was used. The elimination of weed vegetation contributed to the formation of sufficiently high commercial yields of the crop. The maximum commercial yields of 88.0 t/ha and 91.0 t/ha were obtained in the variants with joint application of Lazurite, SP + Aminovit.