Fisheries play an important role in the global food security and are considered the major source of foreign exchange for the foreign trade economies of many countries. The Covid-19 outbreak has caused disruptions in international trade, which has led to consequences related to the production, export of seafood in Vietnam in general and Da Nang in particular. The paper analyzes the seafood export situation of Da Nang City, one of the five cities directly managed by the Vietnamese central government, examining the opportunities and challenges of exporting the city’s fish products before and during the Covid-19 pandemic. The study results show that Da Nang’s seafood export activity in 2020 was significantly affected by the development of the Covid-19 epidemic, with the total seafood export turnover decreasing by 7.6 % compared to the same period of the previous year. While there are positive signs of recovery in the city’s seafood business in 2021, there are still risks of unsustainable growth. Based on the results of the analysis, proposals and policy decisions are substantiated to maintain growth rates and develop the city’s import and export activities in the post-Covid-19 period.