The scientific libraries participate in building the information and communication infrastructure being an integral part of the scientific, educational,socio-cultural and industrial complex of the region. The authors review in brief the evolution of the State Public Scientific and Technological Library of the Siberian Branch of the Russian Academy of Sciences (SPSTL SB RAS) – the leading information and library center of Siberia in the context of changing scientific and educational environment. The Siberian Branch of the USSR Academy of Sciences, established in 1957, contributes to the active development of science in the east of the country. Implementing strategic objectives, among the priority measures the Branch heads laid the new system foundations of research information support, which met the demands of science development and the specific character of the institution activity within the Siberian Branch of the USSR Academy of Sciences. Big efforts to expand the network of libraries of research institutes were undertaken. The State Public Scientific Technological Library of the SB USSR AS, which began its activities in the region in 1958, was designed as the central library of the USSR SB AS (SB RAS). For 65 years, it has been providing information and methodological support for multidisciplinary research. The Library also acts as an institutional center in the library science, bibliography and bibliology, book history, and the largest library and information, cultural, educational, educational center, shaping the modern information, scientific, educational and cultural environment.