Being a traditional institution of culture, knowledge preservation and transfer, a relatively stable form of organizing social life, ensuring strength of ties and relationships within a society, in the context of its systemic transformations, developing digitalization of resources and communications, the library has the potential, the implementation of which can determine new models of action. In this regard, it becomes important to develop a model for adapting the activities of libraries in the region to the modern system of communications. For to elaborate a specific strategy, it is important to comprehend the development of library and information systems in the context of the historical and cultural development. The libraries of Uzbekistan served as the research object of the paper. The process of their systematic formation in this region started in 1918. The Uzbek Soviet Socialist Republic, which entered the USSR, was created in October 24, 1924. Since that time, there began active creation of mass, special scientific, university and scientific technological libraries. The policy of mass library centralization carried out in the USSR in the 1970s–1980s contributed to the centralized collection acquisition, improvement of library services for different population segments, and raising the library personnel qualification. The library system was formed in the republic, which was systematically supported by the state. The article object is, basing on previously published and new information obtained from statistical collections and documents of state archives, which were not examined by specialists, to concretize concepts about forming and developing libraries in Uzbekistan as a part of the USSR library system for to determine future regularities and trends in the republican library and information system development.